MAIL: Memory-driven, Adaptive, Incremental, and Literature-grounded Framework for Hypothesis Generation in Chemistry· MAIL：化学假设生成的记忆驱动框架

The ever-expanding volume of the chemical literature offers unprecedented opportunities to generate novel and impactful hypotheses. However, the bottleneck lies in efficiently navigating this vast knowledge base to formulate high-quality, experimentally meaningful insights. While Large Language Models (LLMs) show promise for this task, existing methods often rely on static inspiration corpora, predefined heuristics, or laborious human-in-the-loop pipelines and decision-support frameworks that limit scalability and novelty. In this work, we propose an automated approach, a Memory-augmented, Adaptive, Incremental, and Literature-grounded (MAIL) framework for hypothesis generation in chemistry. Our MAIL method formulates hypothesis generation as a temporally grounded, memory-driven reasoning